Differential surface expression and possible function of 9- O - and 7- O -acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes
Identifieur interne : 000F72 ( Main/Exploration ); précédent : 000F71; suivant : 000F73Differential surface expression and possible function of 9- O - and 7- O -acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes
Auteurs : Michael Erdmann [Allemagne] ; Dirk Wipfler [Allemagne] ; Anette Merling [Allemagne] ; Yi Cao [Allemagne] ; Christine Claus [Allemagne] ; Bernhard Kniep [Allemagne] ; Haneen Sadick [Allemagne] ; Wolfgang Bergler [Allemagne] ; Reinhard Vlasak [Autriche] ; Reinhard Schwartz-Albiez [Allemagne]Source :
- Glycoconjugate Journal [ 0282-0080 ] ; 2006-12-01.
English descriptors
Abstract
Abstract: The disialoganglioside GD3 (CD60 a) and its O-acetylated variants have previously been described as surface molecules of human T lymphocytes of the peripheral blood system. Here we report the expression of the 9-O-, and 7-O-acetylated disialoglycans of GD3 (CD60 b and CD60 c respectively) on human tonsillar lymphocytes. CD60 b and c are surface-expressed on activated germinal centre B cells and colocalize in raft-like structures on the cell surface together with the cytoplasmic tyrosine kinase Lyn and Syk. Addition of CD60 b and c mAb together with anti-IgM/IL-4 to in vitro cultivated tonsillar B cells resulted in a costimulatory effect. During spontaneous and staurosporine-induced apoptosis a distinct population of activated annexin V+/CD60 b+/CD60 c- B cells was observed. CD60 b and c are also found on cells of the extrafollicular T cell area. On tonsillar T cells, CD60 b mAb had a costimulatory effect together with PHA while CD60 c mAb alone was sufficient to induce proliferation. In further contrast to B cells, during apoptosis a distinct CD60 b+ T cell subpopulation was not observed. Together, surface-expressed CD60 b and c are differently expressed on tonsillar B and T cells and may be involved in the regulation of activation and apoptosis of lymphocytes in secondary lymphatic tissue.
Url:
DOI: 10.1007/s10719-006-9000-5
Affiliations:
- Allemagne, Autriche
- Bade-Wurtemberg, Brême (Land), District de Dresde, District de Karlsruhe, Rhénanie-Palatinat, Saxe (Land)
- Brême, Dresde, Heidelberg, Mannheim, Mayence
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type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Research Center, D010, Im Neuenheimer Feld 280, D-69120, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Glycoconjugate Journal</title><title level="j" type="sub">Official Journal of the International Glycoconjugate Organization</title><title level="j" type="abbrev">Glycoconj J</title><idno type="ISSN">0282-0080</idno><idno type="eISSN">1573-4986</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com</publisher><pubPlace>New York</pubPlace><date type="published" when="2006-12-01">2006-12-01</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="627">627</biblScope><biblScope unit="page" to="638">638</biblScope></imprint><idno type="ISSN">0282-0080</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0282-0080</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ganglioside</term><term>Germinal center</term><term>Lipid rafts</term><term>O -acetylated sialic acid</term><term>Signal transduction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The disialoganglioside GD3 (CD60 a) and its O-acetylated variants have previously been described as surface molecules of human T lymphocytes of the peripheral blood system. Here we report the expression of the 9-O-, and 7-O-acetylated disialoglycans of GD3 (CD60 b and CD60 c respectively) on human tonsillar lymphocytes. CD60 b and c are surface-expressed on activated germinal centre B cells and colocalize in raft-like structures on the cell surface together with the cytoplasmic tyrosine kinase Lyn and Syk. Addition of CD60 b and c mAb together with anti-IgM/IL-4 to in vitro cultivated tonsillar B cells resulted in a costimulatory effect. During spontaneous and staurosporine-induced apoptosis a distinct population of activated annexin V+/CD60 b+/CD60 c- B cells was observed. CD60 b and c are also found on cells of the extrafollicular T cell area. On tonsillar T cells, CD60 b mAb had a costimulatory effect together with PHA while CD60 c mAb alone was sufficient to induce proliferation. In further contrast to B cells, during apoptosis a distinct CD60 b+ T cell subpopulation was not observed. Together, surface-expressed CD60 b and c are differently expressed on tonsillar B and T cells and may be involved in the regulation of activation and apoptosis of lymphocytes in secondary lymphatic tissue.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Bade-Wurtemberg</li><li>Brême (Land)</li><li>District de Dresde</li><li>District de Karlsruhe</li><li>Rhénanie-Palatinat</li><li>Saxe (Land)</li></region><settlement><li>Brême</li><li>Dresde</li><li>Heidelberg</li><li>Mannheim</li><li>Mayence</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Erdmann, Michael" sort="Erdmann, Michael" uniqKey="Erdmann M" first="Michael" last="Erdmann">Michael Erdmann</name></region><name sortKey="Bergler, Wolfgang" sort="Bergler, Wolfgang" uniqKey="Bergler W" first="Wolfgang" last="Bergler">Wolfgang Bergler</name><name sortKey="Cao, Yi" sort="Cao, Yi" uniqKey="Cao Y" first="Yi" last="Cao">Yi Cao</name><name sortKey="Claus, Christine" sort="Claus, Christine" uniqKey="Claus C" first="Christine" last="Claus">Christine Claus</name><name sortKey="Kniep, Bernhard" sort="Kniep, Bernhard" uniqKey="Kniep B" first="Bernhard" last="Kniep">Bernhard Kniep</name><name sortKey="Merling, Anette" sort="Merling, Anette" uniqKey="Merling A" first="Anette" last="Merling">Anette Merling</name><name sortKey="Sadick, Haneen" sort="Sadick, Haneen" uniqKey="Sadick H" first="Haneen" last="Sadick">Haneen Sadick</name><name sortKey="Schwartz Albiez, Reinhard" sort="Schwartz Albiez, Reinhard" uniqKey="Schwartz Albiez R" first="Reinhard" last="Schwartz-Albiez">Reinhard Schwartz-Albiez</name><name sortKey="Schwartz Albiez, Reinhard" sort="Schwartz Albiez, Reinhard" uniqKey="Schwartz Albiez R" first="Reinhard" last="Schwartz-Albiez">Reinhard Schwartz-Albiez</name><name sortKey="Schwartz Albiez, Reinhard" sort="Schwartz Albiez, Reinhard" uniqKey="Schwartz Albiez R" first="Reinhard" last="Schwartz-Albiez">Reinhard Schwartz-Albiez</name><name sortKey="Wipfler, Dirk" sort="Wipfler, Dirk" uniqKey="Wipfler D" first="Dirk" last="Wipfler">Dirk Wipfler</name></country><country name="Autriche"><noRegion><name sortKey="Vlasak, Reinhard" sort="Vlasak, Reinhard" uniqKey="Vlasak R" first="Reinhard" last="Vlasak">Reinhard Vlasak</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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